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Ampicillina sodium salt

Ampicillina sodium salt

International Nonproprietary Name:

Sodium ampicillin

Pharmaceutical form:

Injection solution preparation powder
  • Properties

    Pharmacological properties:

    Ampicillin is a broad-spectrum antibiotic from the semisynthetic penicillins group. It affects bactericidal, suppressing the synthesis of the cell wall of microorganisms. Destroyed under the influence of penicillinase.

    The following microorganisms are permanently sensitive to the drug: Staphylococcus spp., Streptococci A, B, C, F, G, Str. Pneumoniae, not producing penicillinase; L. monocytogenes, Corynebacterium diphtheriae, Erysipelotrix rhusopathiae, Eikenella, N. meningitides, Bordetella pertussis, Clostridium spp., Propioniobacterium acnes, Peptostreptococcus spp., Actinomyces spp., Leptospira spp., Treponema; Are impermanently sensitive:  Enterococcus faecalis, E. coli, Proteus mirabilis, Salmonella spp., Vibrio cholerae, H. influenzae, N.gonorrhoeae, Fusobacterium spp., Prevotella spp.

    The drug is stable to: D. catarrhalis, Klebsiella spp., Enterobacter spp., C.diversus, C.freundi, Proteus vulgaris, Providencia rettgeri, Morganella moryanii, Y.enterocolitica., Pseudomonas spp., Acinetbacter spp., Xanthomonas spp., Flavobacterium spp., Alcaligenes spp., Nocardia spp., Campylobacter spp., Legionella pneumophila, Mycobacterium spp., Bacteriodes spp., Mycoplasma spp., Chlamydia spp.


    After parenteral administration penetrates into tissues and body fluids, it is found in therapeutic concentrations in pleural, peritoneal and synovial fluids, in bile.  The drug penetrates through the placental barrier, and excreted to mother's milk. The half-life (T1 / 2) is approximately 1 hour, with anuria it increases to 12-20 hours. The main part is excreted from the body by the kidney and high concentration of antibiotic is created in the urine.  The drug with repeated administration does not cumulate, which makes it possible to apply it in large doses and for a long time.

  • Indications

    Bacterial infections: Bronchitis, pneumonia, dysentery, salmonellosis, prolonged carriage of salmonella, cholecystitis, whooping cough, pyelonephritis, urethritis, endocarditis, skin and soft tissue infections, gynecological infections, ear infections, throat, nose, odontogenic infections, meningitis, sepsis and other infections caused by sensitive to the preparation by microorganisms.

  • Contraindications
    Hypersensitivity (including other penicillins, cephalosporins, carbapenems), severe violations of the liver, infectious mononucleosis, bronchial asthma, hay fever, breastfeeding (during treatment, it is necessary to stop breastfeeding).
  • Dosage and Administration

    Parenteral: With both methods of administration to adults, 250-500 mg 4-6 times a day; In severe infections (sepsis, meningitis, endocarditis), the daily dose can be increased to 10 g or more; Children depending on the age in a daily dose:  Newborns 100 mg / kg, under 1 year 50 mg / kg, 1 to 4 years 50-75 mg / kg, over 4 years 50 mg / kg.

    With a single dose exceeding 2 g, injected / in the drip. For this 2-4 g are dissolved in 7.5-15.0 ml of sterile water for injection, then 125-250 ml of isotonic sodium chloride solution or 5-10% glucose solution are added to the resulting solution, it is injected at a speed of 60-80 drops in a minute.

    In i/v injection, 5-10% glucose solution (30-50 ml depending on the age) is used as a solvent for children.

    The duration of treatment depends on the severity of the condition and the effectiveness of therapy (from 5-10 days to 2-3 weeks or more).

    Solution for the i/m introduction is prepared ex tempore, adding to the contents of the bottle 2 ml of sterile water for injection or 0.5% solution of novocaine for injection (except for patients who have increased sensitivity to novocaine).

    For intravenous administration of a single dose of the drug (not more than 2 g) is dissolved in 5-10 ml of sterile water for injection or isotonic sodium chloride solution, injected slowly. 

  • Drug form
    500 mg powder to prepare an injection solution.