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Allercetin rino

Allercetin rino

International Nonproprietary Name:

Naphazoline nitrate, diphenhydramine hydrochloride

Pharmaceutical form:

Eye and nasal drops
  • Properties

    Pharmacokinetics

    Active substances of the drug Allercetin Rino, when administered locally, can be absorbed into the systemic blood circulation and exert a resorptive effect.

    The therapeutic effect appears 5 minutes after the instillation of the drug and lasts up to 6 hours, the effect duration can be reduced up to 4 hours with frequent use of the drug.

     

    Pharmacodynamics

    Allercetin Rino has an anti-allergic and vasoexcitatory effect due to the content of naphazoline and diphenhydramine. 

    Diphenhydramine, which is component of the drug, is  H1 antagonist, has H1 -blocking activity, reduces or prevents spasms of smooth muscles caused by histamine, increasing of capillary permeability, edema of tissues, itching, and hyperemia.

    Nafazolin has a fast, long-lasting vasoconstrictive effect for the mucous membranes vessels (reduces swelling, flushing, exudation).  Naphazoline when administrated internasally eases nasal congestion in rhinitis. It promotes opening and expansion of paranasal sinuses paths and clears blocked Eustachian tubes.  It simulates secretion discharge and prevents the deposition of bacteria on the nasal mucosa.  

  • Indications

    • aggrevation of seasonal allergic conjunctivitis;

    • aggrevation of year-round allergic conjunctivitis;

    • conjuctival irritation caused by contact lenses;

    • conjuctival irritation caused by impact of external factors(including sunlight, cigarette smoke, water in the swimming pool; 

    • acute rhinitis;

    • allergic rhinosinusitis;

    • allergic vasomotor rhinitis.
  • Contraindications

    • hypersensitivity to any component of the drug;

    • conjunctival xerosis (dry keratoconjunctivitis, Sjögren's syndrome);

    • angle closure glaucome;

    • arterial hypertension, tachycardia, severe atherosclerosis;

    • diabetes;

    • hypertrophy of the prostate;

    • hyperthyroidism;

    • simultaneous administration of monoamine oxidase inhibitors and a 14 days after the end of administration;   

    • children under 2 years old (0.03%).

  • Dosage and Administration

    In rhinitis: adults use 2-3 drops (0.06%) in each nostril 3 times a day.

    Children use 0.03% drops:

    -2 to 6 years old age - 1-2 drops in each nostril 1-2 times a day

    -6 to 15 years old age - 2 drops in each nostril 3 times a day

    Therapy regimen is 5-6 days.

    In conjunctivitis:

    Adults use 0.06% drops:  In acute events - 1 drop every 3 hours in the conjunctival sac until the edema and eye irritation decrease, then 1 drop 2-3 times / day until the clinical symptoms disappear. Children over 2 years use 0.03% 1-2 drops / day.  Do not apply for more than 5 days. If the symptoms of irritation of the conjunctival irritation persist for more than 72 hours, the drug use should be discontinued.

    When instilling, avoid the contact of the dropper bottle tip with other objects or surfaces. After instillation the dropper bottle cap should be tightly closed! 

  • Drug form
    10 ml in polypropylene (plastic) bottles with a spray cap and protective cap.